Caverject (alprostadil) is a prostaglandin that has many different pharmacological actions, including vasodilation and inhibition of platelet aggregation. Alprostadil (prostaglandin E1) is produced internally in order to relax the smooth muscles in the vascular system and cause vasodilation. Alprostadil is produced endogenously and causes vasodilation through its direct action on the vascular smooth muscles and ductus arteriosus (DA), either by blocking or by reversing the functional closing of the DA which occurs soon after birth. Alprostadil is also used to maintain a patent ductus arteriosus in newborns.
Alprostadil for sale can potentiate the effects of antihypertensive, vasodilating agents, blood thinners, and platelet-aggregating inhibitors. Topical alprostadil cream has proven an effective, well-tolerated treatment for erectile dysfunction (ED) and may be used safely by men who are receiving treatment with alpha-blockers, antihypertensive agents, and/or nitrates.
Effects on ED
The pharmacologic effects of alprostadil in treating ED are thought to be mediated through inhibition of alpha 1-adrenergic activity in the penile tissues and through its relaxation effects on the cavernosal smooth muscles. The pharmacologic effect of alprostadil in the treatment of erectile dysfunction is presumed to be mediated by inhibition of alpha 1 -adrenergic activity in penile tissue and by its relaxing effect on cavernosal smooth muscle. This, in turn, triggers the activation of adenylate cyclase, which results in the accumulation of 35-cAMP (cyclic adenosine monophosphate), responsible for the drugs pharmacologic effects, including smooth muscle relaxation, vasodilation (increased peripheral blood flow; helps with erectile dysfunction) and bronchodilation, as well as suppression of platelet aggregation. Alprostadil binds as an agonist to prostaglandin receptors, e.g., EP2 which in turns activates adenylate cyclase leading to accumulation of 35-cAMP (cyclic adenosine monophosphate) which is responsible for the pharmacologic effects of the medication including smooth muscle relaxation, causing vasodilation (increasing peripheral blood flow ; helps in erectile dysfunction) and bronchodilation, and inhibits platelet aggregation. It increases intracellular levels of cyclic adenosine monophosphate (cAMP) by regulating adenylate cyclase.
It has a diverse pharmacologic profile, among which some of its most significant effects are vasodilation, platelet aggregation inhibition, inhibition of gastric secretion, and stimulation of smooth bowel and uterine muscles. Administration of intracavernous alprostadil is helpful due to its vasodilating properties, which work by relaxing the corpus cavernosum smooth muscles, thus increasing cavernous arterial diameter, leading to an erection. Injections of alprostadil induce erections as it increases the flow of blood into the penis. It belongs to a group of medicines called vasodilators, which may increase blood flow by expanding blood vessels.
Alprostadil injections are used by themselves or in combination with medical tests to help diagnose erectile dysfunction, which can be caused by nerve or blood vessel problems in the penis. Alprostadil injection should not be used as a sexual aid for men who do not have erectile dysfunction (ED). If alprostadil injection is used improperly, permanent damage to the penis and loss of erection capacity may occur. Intravenous injections with phentolamine, papaverine, and Alprostadil are considered the second-line treatments for Erectile Dysfunction (ED), though alprostadil is the most frequently used.
Alprostadil is sold as a urethral suppository and as an injectable form in the U.S. Alprostadil comes in powder to mix with a liquid provided in the packaging and injected into your penis, and as urethral suppositories (pellets that are placed into your penile orifice). In adults, alprostadil is used to treat erectile dysfunction caused by neurogenic, vasculogenic, psychogenic, or a combination of causes.